RPM wears parts. Good oil and filters help to reduce this.
Some mods actually help to decrease stresses, and improve efficiency.
Any mod which increases chamber pressure, will cause more wear on rings and bores. Very minutely.
Any mod which reduces heat in the engine (up to a point), will reduce wear in the engine.
So unless you are more specific in which mods you are asking about, there is not a lot more that can be said.
Some mods actually help to decrease stresses, and improve efficiency.
Any mod which increases chamber pressure, will cause more wear on rings and bores. Very minutely.
Any mod which reduces heat in the engine (up to a point), will reduce wear in the engine.
So unless you are more specific in which mods you are asking about, there is not a lot more that can be said.